Beta blockers vary in whether they're eliminated by the kidneys or liver. Lipid-soluble drugs, such as labetalol, mertropolol, pindolol, and propranolol, tend to clear through hepatic metabolism, whereas water-soluble drugs such as atenolol are cleared by the kidneys. The ones eliminated by the liver often have more variable bioavailabilities.
The half life of many beta blockers is relatively short. The half life is somewhat extended in those drugs eliminated by the kidneys due to their increased reabsorption.
("Drug Classes", 2008)
The half life of many beta blockers is relatively short. The half life is somewhat extended in those drugs eliminated by the kidneys due to their increased reabsorption.
("Drug Classes", 2008)